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These are molecules which are man-made, and they bind to the receptors in our bodies. They work the same way that the natural ones do and are usually just called SCBs.  Some are illegal, but not all of them. They pretty much work to replicate the same structure and effects of both THC and CBD, but do they work in the same manner? There is a market for both types, as well as somewhat-synthetic cannabinoids which get derived from hemp, which have escaped regulation. However, just because the laws aren’t caught up, doesn’t mean that synthetic cannabinoids aren’t risky. Learn more about the products and the risk associated with this as well.

How do they Work?

They work in the same way traditional cannabinoids do in that they keep our systems in balance. THC and other cannabinoids are broken down quite rapidly by the ECS, so it’s definitely not possible to overdose in a lot of cases, and there isn’t much risk for this. Synthetic ones don’t have the natural checks that the natural ones do, and they may not break down as quickly either. 

THC is an agonist of CB1. Synectic cannabinoids can be more agnostic though, creating more deadly effects that may be a bit too much. HU-210 is a very potent one for example. They also do work with other receptors too including serotonin, NMDA glutamate, and dopamine, and this is a substance that’s actually potentially dangerous compared to the natural cannabis types. It’s also not just the SCB itself that breaks it down, but the metabolites as well, since they can be very toxic at some levels, and it can sometimes have some very strong medical uses in some cases, but the side effects should be monitored.


These synthetic ones are used under medical supervision, and they can actually targe the receptors in a more effective manner than normal cannabinoids. The cannabis plant comes with hundreds of compounds, all of which work together this type of synergy is called the entourage effect, and it’s advantageous to the safety of a person, and also mitigates the adverse reactions, but also can be disadvantageous in some cases, especially if you’re trying to target one kind of effect. CBDA and THCA are definitely unstable too and will become their regular acidic compounds when they get oxygen and sunlight. The synthetic versions of these can be made to create a stable product, and it also can be semi-synthetic too, which can be changed to benefit the stability. 

Delta-8 and THCO for example do come from hemp, and this can e a bit more risky due to the industrial methods used for this. There is also not a ton of research either, or sometimes the chemical pollutants in this can be a danger in it of itself as well. There are a few drugs however that are made from this. Nabilone for example is synthetic THC made specifically for HIV, AIDS, and cancer patients. This does come with risks though, since they’re not as tolerated by the body, and they’re not as tested. We also don’t know as much about how this reacts directly with the ECS. It also does have some serious health concerns too, including addiction, significant depression of breathing, injury of the kidneys, stroke, tremors, cardiac issues, dangerous levels of potassium in the blood, a break down of the skeletal system as well. If you do try to use these do make sure that they’re safe enough for you to do so when you’re able to, and also make sure that the doctor is aware of everything.

Clinical Endocannabinoid Deficiency

The ECS is a network of different parts of the body that are mostly responsible for improving the bodily function of a human and controlling their organs too. With the ultimate goal to maintain proper homeostasis within the body, keeping it stable regardless of the external parts and influences, it’s something that can definitely make changes to the body. There are different deficiencies that are out there such as endocannabinoid deficiencies, and this is something that doesn’t affect the body well, resulting in migraines, other conditions, pain of the muscles, and even IBS in some cases. 

The clinal Deficiency

This is called clinical endocannabinoid deficiency, and this is built with the idea that some conditions may be linked to ECS problems. The theory came about in 2001 and since then has been a part of a lot of studies, and even came about in 2004 from other psychopharmacology research too. Migraines, fibromyalgia which causes pain in the body, fatigue, sleep issues, and a lot of emotional problems, IBS, and other problems are all due to the deficiency of this, and the symptoms that are there as a result. The body may not be creating enough endocannabinoids, or some of them may have missing or messed up receptors. When this comes about, the body doesn’t have proper balance, and the diseases that are linked to your immune system happen as a result of this. The studies from Russo who discovered this did continue, and he later on did confirm that the best evidence for this is actually seen in those with these conditions, since these have different trends that all have them being similar in nature. 

Phantom pain, cystic fibrosus, neonatal failure to grow, causalgia, brachial plexopathy, glaucoma, dysmenorrhea infantile colic, hyperemesis, and even fetal wastage such as miscarriages that happen a lot along with PTSD and bipolar are all linked to these deficiencies that are there. In terms of fibromyalgia, IBS, and migraines, they all had the same conditions. First, they each were diagnosed based on criteria which was subjective and they all didn’t have tissue pathology or good findings in the lab. They all were diagnosed and generated negative results, and usually this happened after other possibilities were there. There were instances of both depression and anxiety, and were considered psychosomatic The stimulus of two diseases or mor happened with this, and headaches were a big part of this, and usually, they all had conditions which were mingling with one another. 


Right now, there isn’t much research on this, and right now, there isn’t much research on this, why it happens, and the best way to treat it. The makeup of your genes, the injuries that you have, and other diseases are oftentimes linked as probably causes, but none of this had confirmation. This is usually something that happens due to improper balancing of the body, not enough endocannabinoid production, and the signaling does result in both depression and anxiety. This also helps with regulating the metabolism of the bone too, since they are a part of this. The best way to actually treat this it to intake cannabinoids, and also use aerobic exercise, a diet that has a fatty acids and other healthy fats also is a big part of this. 

THC should be taken but keep this in low amounts and you should try to go for CBD, CBG, CBN, and other compounds to directly target the receptors. These are all the best ways to treat it, as the research at the current moment is still not all there, but we may have something more later.